Category: Main Projects
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Glial contribution to synaptic dynamics and diseases
The nervous system comprises two broad classes of cells: neurons and glia. Neuroscientists once believed that only neurons were responsible for information processing, and glia were merely supportive. This dogma is now being challenged, as recent studies have shown that glia are integral to neuronal circuit reorganization and are implicated in many neuropathologies. My early…
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Cortical circuitry modification in stress and psychiatric disorders
Stress pervades modern life. It is a major risk factor for many psychiatric disorders. As sensorimotor abnormalities are often present in these disorders, and mouse sensory cortices are accessible for in vivo imaging studies, we focused on the somatosensory cortex in the initial investigations. Combining behavioral analyses, chronic synaptic imaging, and cell type-specific manipulations, we…
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Synapse remodeling in learning and memory formation
Synapses are the principal sites at which neurons contact and communicate with one another. Experience-dependent modification of synaptic structure and function provides a cellular mechanism for learning and memory. My lab studies how the neuronal circuitry is established during development, and how it is rewired during learning and memory formation. We have established several mouse…
Guy the Cat Consulting 